Inhibitory Effects of Furanocoumarin Derivatives in Kampo Extract Medicines on P-Glycoprotein at the Blood-Brain Barrier
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چکیده
منابع مشابه
Inhibitory effects of furanocoumarin derivatives in Kampo extract medicines on P-glycoprotein at the blood-brain barrier.
Furanocoumarin derivatives, known as components of grapefruit juice, showing inhibitory effects against P-glycoprotein (P-gp) in the intestine are also contained in the plants of rutaceae and umbelliferae families, which are used as components of Kampo extract medicines. In this study, we investigated the inhibitory effects of byakangelicol and rivulobirin A, known as furanocoumarins showing P-...
متن کاملFuranocoumarin derivatives in Kampo extract medicines inhibit cytochrome P450 3A4 and/or P-glycoprotein
Furanocoumarins in grapefruit are known to show inhibitory effects against P-glycoprotein and/or CYP3A4 in intestinal epithelial cells; however, furanocoumarin derivatives are widely contained in the plants of rutaceae and umbelliferae families, which are used as components of Kampo extract medicines. In this study, we investigated the inhibitory effects of 12 furanocoumarins extracted from pla...
متن کاملFuranocoumarin derivatives in Kampo extract medicines inhibit cytochrome P450 3A4 and P-glycoprotein.
Furanocoumarins in grapefruit are known to show inhibitory effects against P-glycoprotein (P-gp) and CYP3A4 in intestinal epithelial cells; however, furanocoumarin derivatives are widely contained in the plants of Rutaceae and Umbelliferae families, which are used as components of Kampo extract medicines. In this study, we investigated the inhibitory effects of 12 furanocoumarins extracted from...
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Introduction: Recent studies have reported that the Aloe vera (Aloe barbadensis miller) plant has anti-inflammatory and antioxidant effects. This study evaluated the neuroprotective effects of different doses of Aloe vera extract after traumatic brain injury (TBI) in male rats. Materials and Methods: In this study, 70 male rats were divided into 2 groups; each group consists of 5 of sub-g...
متن کاملThe Role of P-glycoprotein in the Blood-Brain Barrier
The blood-brain barrier is composed of specialized endothelial cells that prevent various substances from entering the brain. P-glycoprotein is an important component of this barrier and is present in high concentration on the apical surface of these endothelial cells. It is an ATP-dependent transport protein thought to be involved in extruding a variety of structurally unrelated compounds and ...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2011
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.34.1246